Nearby Reykjavik City Airport is the departure airport for domestic flights in Iceland such as Isafjordur.
Isafjordur is easy to reach by plane. There is a flight twice a day. From the airport you can get to the ship by bus, which stops at the hotel just 2 minutes walking away from the harbour. Or you can rent a car and drive. It is possible to rent the car and leave it on the airport on both sides. Take some time and see more of Iceland along the way!